Test S of Haplotype Concordance and Discordance

Mahnaz Khattak, Shuhrat Shah, Salahud Din

Abstract


The test presented here is based upon the proband and his/her affected as well as unaffected siblings. Here, the siblings are analyzed in terms of similarities of haplotypes. The proposed ‘S’ test is used in testing hypothesis that a particular disease has random pattern of inheritance against the alternative hypothesis that it has non-random pattern of inheritance. Probability distribution, mean and variance of the test are derived under the null hypothesis of random inheritance of the disease. It is then applied to data set of varying size of sibships having at least one affected and one unaffected sibs to investigate the existence of linkage disequilibrium.

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DOI: http://dx.doi.org/10.18187/pjsor.v3i1.76

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Title

Test S of Haplotype Concordance and Discordance

Keywords

-

Description

The test presented here is based upon the proband and his/her affected as well as unaffected siblings. Here, the siblings are analyzed in terms of similarities of haplotypes. The proposed ‘S’ test is used in testing hypothesis that a particular disease has random pattern of inheritance against the alternative hypothesis that it has non-random pattern of inheritance. Probability distribution, mean and variance of the test are derived under the null hypothesis of random inheritance of the disease. It is then applied to data set of varying size of sibships having at least one affected and one unaffected sibs to investigate the existence of linkage disequilibrium.

Date

2007-01-01

Identifier


Source

Pakistan Journal of Statistics and Operation Research; Vol 3. No. 1, Jan 2007



Print ISSN: 1816-2711 | Electronic ISSN: 2220-5810